Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
Γ-secretases are ubiquitously expressed intramembrane proteases best known for their pathogenic roles in Alzheimer’s disease (AD) (1). Aberrant processing of the amyloid precursor protein (APP) by γ-secretases leads to the production of longer, aggregation …